Archive for the ‘MPB Treatment and Cures’ Category

Good Times

Wednesday, November 3rd, 2010

This particular arena of medical science research  is very progressive currently. These are good times for anyone suffering from hairloss and or male/female pattern baldness

Food & Vitamins

Monday, September 20th, 2010

Food & Vitamins:

Protein: Your hair is made of 98 percent protein, and it needs special nutrients just as much as the rest of your body does. So you can probably guess what your key nutrient is when it comes to healthy hair. Since hair loss is associated with a high-fat diet, you need to get the majority of your protein from low fat sources such as fish, poultry, and legumes such as soy. However, although protein is the basic building block, too much protein can also cause unhealthy hair by making the body too acidic. Too much protein will also cause a calcium deficiency, which will deplete it from your hair and even your nails. Protein is vital for the healthy hair development cycles. In case you are a vegan or you on a diet, be certain to make sure that your body obtains the essential protein.

Vitamins: There are minerals and vitamins which help in the development of healthy hair. The opinion of your family doctor is very important to know if your severe hair fall is due to the insufficiency of any vitamins. Being part of a high stress, pressurized lifestyle can sometimes make it is next to impossible to have good food habits. The effect is a shortage of vitamin. And this along with common weakening of health causes hair fall as well. Following are the top vitamins for hair growth:

Vitamin A: Vitamin A is another essential requirement for healthy hair. One of the signs of vitamin A deficiency is hair loss. If you’re eating your 5 or more servings of fruits and vegetables, you’ll be getting lots of vitamin A in yellow and orange vegetables and fruits, and dark green leafy vegetables such as kale and broccoli. Other sources of vitamin A are liver, egg yolks, milk, and butter. Be careful though of taking oral Vitamin A supplements, especially if you are a woman in the reproductive age group, as there are unconfirmed fears that Vitamin A in excess can cause birth defects, if you do happen to get pregnant while on them.

Vitamin B Group: All of the B vitamins are also important for healthy hair, especially biotin. Animals lacking biotin develop eczema and their hair falls out. The richest source of biotin is yeast.
Being bald has been attributed to the dearth of Vitamin B in a person’s body. Vitamin B5 enhances the growth of hair due to the presence of pantothenic acid and B3 also called as niacin. B6 is similarly significant to the body, because it helps in the processing of nutrients such as other biotin vitamins, zinc, sulfur and magnesium.

Antioxidants – Vitamin C, E and beta carotene come in this group of vitamins that are known as antioxidants. Either a pill or a food resource can fulfill your daily vitamin overages.

Vitamin E: Vitamin E is another key vitamin for healthy hair.The only source of Vitamin E for vegetarians is green leafy vegetables like spinach, parsley, mustard green and broccoli, whole grains and nuts like sunflower seeds and almonds. Other food sources are unrefined, extra virgin olive oil, whole grains, avocados, and nuts.

Vitamin C: All types of citrus foods and a few vegetables such as tomato are good source of vitamin C. Beta carotene is found predominantly in fruits and vegetables having a yellow or an orange color such as apricots, carrots and cantaloupes.

Essential Fatty Acids: Everybody needs essential fatty acids found in Omega 3 for strength of hair. Omega 3 fatty acids are present to the maximum extent only in sea foods like salmon, tuna and halibut. Olive oil in addition to certain nuts such as flaxseeds and walnuts also give the body omega 3.

Minerals: The minerals as zinc, silica, selenium, sulfur, potassium and manganese are very crucial for improving and enhancing the strength of hair. The majority of such minerals could be found in poultry products such as chicken and egg, meat, as well as dairy products such as  cheese and milk. Pumpkin seeds are the vegetarian basis of zinc.

Iron – Iron deficiency is a general cause of hair fall. This deficit causes sluggish blood circulation to scalp as well as therefore the hair follicles are poor of nutrients necessary for their healthy growth.

– One can augment the strength of hair by including iodine on one’s diet. Hair fall can also be a resultant of hypo-thyroidism (decreased thyroid hormones in the body) which depletes the iodine in our body. It is better to go for natural foods to supplement our body’s requirement of iodine found in salmon, seafood, potatoes, molasses, lima beans, eggs, watercress, garlic and seaweed.

These are the most necessary vitamins and minerals and are excellent for healthy and increased growth of hair.

As far as Food here are the top five foods for healthy hair:

When it comes to foods that pack a beauty punch, it’s hard to beat salmon. Loaded with omega-3 fatty acids, this high-quality protein source is also filled with vitamin B-12 and iron.

Popeye the Sailor Man didn’t eat all that spinach for healthy hair, but he could have. Spinach, like broccoli and Swiss chard, is an excellent source of vitamins A and C, which your body needs to produce sebum. The oily substance, secreted by your hair follicles, is the body’s natural hair conditioner. Dark green vegetables also provide iron and calcium.

Legumes like kidney beans and lentils should be an important part of your hair-care diet. Not only do they provide plentiful protein to promote hair growth, but ample iron, zinc, and biotin. While rare, biotin deficiencies can result in brittle hair.

Walnuts contain alpha-linolenic acid, an omega-3 fatty acid that may help condition your hair. They are also a terrific source of zinc, as are cashews, pecans, and almonds. A zinc deficiency can lead to hair shedding, so make sure nuts are a regular on your healthy hair menu.

Without adequate protein or with low-quality protein, one can experience weak brittle hair, while a profound protein deficiency can result in loss of hair color. Poultry also provides iron with a high degree of bioavailability, meaning your body can easily reap its benefits.


Wednesday, July 22nd, 2009

ICX-TRC is an autologous hair regeneration therapy, a suspension of human dermal papilla (DP) cells, for the treatment of male pattern baldness and female diffuse alopecia. DP cells stimulate the generation of new hairs when injected into the scalp in close proximity to the epithelial cells which generate new hair.  It is intended that ICX-TRC will be used by specialists in hair transplant centres, dermatologists and plastic surgeons to treat patients with hair thinning or hair loss.Background

Both male pattern baldness and female diffuse alopecia result in hair-loss or slowing of hair growth.  They may be caused by physical damage to the hair itself or to the hair follicles, but commonly arise as a consequence of changes in the natural growth cycle of hair generally resulting in fewer dermal papilla cells.   Approximately 95% of all cases are of genetic origin.

Market opportunity


Hair loss affects approximately 40% of men and 20% of women aged 50 and over.  In the US there are an estimated 40 million men and 12 million women suffering from some degree of baldness.  The estimated market size for hair regeneration products and treatments is over $1 billion for both men and women but only 2% of patients suffering hair loss currently seek any treatment indicating a potentially far higher market size*. 


dermal papilla cells being grown in cell mediaExisting conventional treatments, involving the transplant of whole hairs, represent the only means of regenerating bald or thinning areas. This is a highly costly ($10,000 – $20,000) specialist procedure.  Extensive tissue is required, obtained by the removal of a large section of scalp leaving a significant scar at the donor site.  Individual follicles are removed from the dissected scalp by specialised technicians and then individually re-implanted into surgical incisions created in the scalp.  This procedure usually takes place during two, eight-hour implant sessions performed under a local anaesthetic.  A lengthy recovery period may be required during which time the patient may suffer from pain, bleeding and swelling of the scalp. In general the cosmetic effect is excellent, however in all cases, the quality of outcome is limited by the amount of donor hair available. Moreover, many individuals electing to undergo this procedure do not progress to transplant surgery as they have insufficient transplantable hair follicles to benefit from the technique as between 2,000 – 5,000 follicles are often needed for this procedure.


The ICX-TRC procedure is significantly less problematic than conventional hair transplants.  In terms of the amount of tissue taken from the patient, only a small sample of approximately 120 follicles is needed.  As a consequence, trauma suffered by the patient during the procedure may be dramatically reduced.  Furthermore, as dermal papilla (DP)cells can be derived from a very small area of hair-bearing scalp, a much higher population of patients will be able to benefit from ICX-TRC than conventional transplantation.  Superficial injection of cultured cells into the scalp causes far less tissue damage than implanting multiple hair follicles and is a considerably simpler, shorter and less painful process.

The ICX-TRC procedure

A small sample of hair follicles is taken from the patient during a simple 30 minute operation carried out under local anaesthetic at a hair or skin clinic. The clinic sends the biopsy to Intercytex’ GMP compliant manufacturing facility where the DP cells are dissociated from the rest of the follicle. These cells are cultured and expanded in proprietary media over three weeks and subsequently returned to the clinic in a sterile suspension.

Thumbnail image of procedure for ICX-TRC – click to open full-size image

Using a specialised delivery system, the DP cells are microinjected intradermally into the patient’s scalp. The treatment is performed under local anaesthetic and comprises a single procedure of superficial injections, each injection delivering a minute volume of media containing DP cells.  These cells are able to stimulate the generation of new hairs when injected in close proximity to the epidermal cells which generate the hair. Following the procedure, new hair growth should become evident after approximately three months.

ICX-TRC clinical and commercial development


Phase I clinical trials (safety) have been completed in seven volunteers at a single UK transplant centre.  No safety issues have arisen and five out of seven patients have shown increased hair numbers. 


A Phase II study, which was conducted by Dr Bessam Farjo in Manchester, is now complete. 


This trial was designed to examine the effect of different DP delivery techniques and methods to ensure that the epidermal cells were in the correct state to respond to the signals and produce new hairs.

In this study, subjects were injected 900 times with 1µl aliquots of DP cells in a large area which was photographed at the end of the study. Subjects were also injected in a smaller area, divided into two sections –  counts were obtained by shaving and photographing the two small sections of scalp, injecting them multiple times (either 1 injection of 50 µl or 50 injections of 1 µl) with living DP cell suspension and then applying a specialised image analysis system to provide a total hair count. In these small sections, all 19 subjects in the trial were treated using a range of injection and scalp pre-stimulation techniques; the first 6 subjects were injected without stimulation of the scalp. In the remaining 13 subjects the resident hair producing (epithelial) cells were stimulated at the time of delivery of the DP cells in one of the two treatment sites.


13 subjects completed the 48-week trial with 6 subjects lost to follow-up. Of the 13 subjects completing the trial the data showed that:


·         65% (11/17) of the treated sites in the non-stimulated group responded to the treatment by increasing numbers of hairs of all sizes


·         71% (12/17) of the treated sites in the non-stimulated group responded to the treatment by increasing numbers of hairs over 30 micron in diameter


·         78% (7/9) of the treated sites in the stimulated group responded to the treatment by increasing numbers of hairs of all sizes


·         100% (9/9) of the treated sites in the stimulated group responded to the treatment by increasing numbers of hairs over 30 micron in diameter


·         The overall take rate (number of hairs produced per 100 injections) in the stimulated areas was

o    40% (n=6) for hairs of all sizes

o    18% (n=6) for hairs over 30 micron in diameter


The larger (900 injection) area photographs have not yet been analysed.


These data are consistent with the interim data reported last September and further confirm the hypothesis that new hair production is improved by pre-stimulation of the scalp, leading to an interaction between the injected cells and the resident hair producing cells.


Dr Bessam Farjo, the Principal Investigator for this study, said “We have learned a lot from this trial, including the different ways in which these cells can be delivered and that it is possible to do one thousand of these injections in a relatively short period of time and at little discomfort to the patient.  I am very encouraged by this data both in the increase in the total number of hairs in the treated site but more importantly by the increase in thicker hairs, those over 30 micron.” 


Further results of the trial will be presented later in the year.



Intercytex is exploring partnering opportunities to continue the next clinical phase of development of ICX-TRC.


Wednesday, July 15th, 2009

I had come along to give my 2cents after listening to a documentary  on stemcells but instead were rewarded with feedback from Histogen! Is Histogen concept only useful if you still have hair? After reading demoralised posters about when if ever we will see  something promising and then reading about scientists having created  artficial sperm, and using temcells from a tooth to restore sight in  a person, and also about preperations to commence injections of  stemcells to restore paralysis and the ability to grow new organs,  i.e trachea in spain last year, it really does not not take a giant  leap to hear scientists have cracked growing hair does it? well they  have just not cosmetically appealing.Anyhow i think its briliant Histogen have posted, i feel inspired



Wednesday, July 15th, 2009


Hello all! We received a request from a poster to provide an update  on this forum. We are pleased to share the news that an interview with Histogen CEO Dr. Gail Naughton will be published in the official journal of the ISHRS, and includes some updates that may be of interest. Please look for this online within the next 2 weeks.

 Additionally Dr. Craig Ziering, hair restoration specialist and  primary investigator on Histogen’s hair regrowth clinical trial, will  indeed be presenting findings from the trial at the upcoming ISHRS  International Meeting in Amsterdam. Histogen plans to address the  presentation in a press release soon.

 Please feel free to contact us through our website with any questions:

Kids Shunned for Hair Loss Get Help From Their Own Stem Cells

Sunday, July 12th, 2009

July 10 (Bloomberg) — Children with alopecia areata, a condition that causes extensive, sometimes complete hair loss, grew hair after being injected with stem cells drawn from their own scalp in a small study.

Most of the five girls and three boys who had widespread baldness showed regrowth of as much as half of their hair in a preliminary study from Marwa Fawzi, a dermatologist at the University of Cairo Faculty of Medicine. Before the experimental treatment, some of the children had splotches of hair and baldness; others were almost totally bald.

Alopecia areata can occur at any age in either gender and there are no FDA-approved treatments, according to the National Alopecia Areata Foundation. Researchers believe people may be genetically predisposed to the condition, which can be aggravated by stress, Fawzi said. Children who get it are often shunned and teased by others, she said in an interview today at the annual meeting of the International Society for Stem Cell Research in Barcelona, Spain, where she presented her findings.

“It’s an emotionally devastating disorder for children,” she said.

Alopecia areata is distinct from the more common male pattern baldness that many men endure as they age. Fawzi has not tested the stem-cell injection treatment for male pattern baldness.

The Cairo researcher took small amounts of skin from the scalps of the children, isolated the hair follicle stem cells that stimulate hair production, and grew them in the lab, increasing the number of cells. After one month, she put the cells back into the scalps of the children, with numerous injections across the bald areas of their heads.

Hair Regrowth

She evaluated the children at one, three and six months after the injections. At the six-month mark, five of the children had at least a 50 percent increase in the amount of hair on their heads, two patients had a smaller increase and one had no change in quantity of hair, she said.

She also took new skin samples and examined the hair follicles themselves and could see that the injected stem cells had migrated into the follicles. There, the stem cells stimulated the follicles to transition from a dormant phase to a hair-generating phase, Fawzi said.

In a poster that she presented at the meeting, she showed photographs of an 8-year-old boy named Mahmoud who was almost completely bald before the treatment and had a nearly full head of hair afterward.

Mahmoud was socially isolated before and always wore a hat to hide his baldness, she said. He now calls her almost every day to talk and thank her for the treatment.

Fawzi plans a larger study of at least 30 children to test the treatment. Each child will receive stem-cell injections in some of the bald areas of their head and placebo injections in others. She will then be able to evaluate the differences in a controlled way, she said.

If the treatment works, she plans to look into its usefulness for androgenic alopecia, better known as male pattern baldness.

To contact the reporter on this story: Rob Waters in San Francisco at

Follica Looking for help!

Monday, June 29th, 2009

Follica, Inc is adding two Research Associates to work in our Philadelphia location. The successful candidate must be able to organize and plan to efficiently manage and execute assigned studies involving animals, cell culture, and protein analysis.

Duties include independent planning, management, and execution of assigned projects involving animals and human tissue.These include drug dosing, surgical procedures, maintenance of a mouse colony, processing of mouse and human tissues, and confocal microscopy.Additional duties include cryostat sectioning of mouse and human skin, biochemical assays, and immunohistochemistry.Maintaining accurate laboratory records and notebooks is required.​ Good teamwork, oral, written skills, problem solving and analytical skills are essential.​ A strong emphasis will be placed on the timely delivery of results on multiple, independently managed projects.

Hello Fellow MPB Bloggers

Monday, June 29th, 2009

Welcome to StayGifted. Believe in who you are and what you represent. Stay true to yourself and your beliefs. Support others who believe in the same things you do, for as a group of believers
travel farther than the single non-believer….we will be successful…